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Trends Mol Med ; 26(12): 1078-1085, 2020 12.
Article in English | MEDLINE | ID: covidwho-807615

ABSTRACT

An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.


Subject(s)
COVID-19/complications , Cytokine Release Syndrome/etiology , Systemic Inflammatory Response Syndrome/etiology , Adolescent , COVID-19/etiology , COVID-19/immunology , COVID-19/virology , Child , Child, Preschool , Cytokine Release Syndrome/immunology , Cytokine Release Syndrome/virology , Cytokines/blood , Host Microbial Interactions/immunology , Humans , Models, Immunological , Pandemics , SARS-CoV-2/immunology , SARS-CoV-2/pathogenicity , Systemic Inflammatory Response Syndrome/immunology , Systemic Inflammatory Response Syndrome/virology , Young Adult
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